[CITATION][C] Genes, microbes, and T cells—new therapeutic targets in Crohn's disease
CO Elson - New England Journal of Medicine, 2002 - Mass Medical Soc
CO Elson
New England Journal of Medicine, 2002•Mass Medical SocNOD2, a gene conferring susceptibility to Crohn's disease, has been identified on
chromosome 16. Homozygosity for a mutation that truncates the gene increases the risk of
Crohn's disease by a factor of 20 to 40. No such mutations have been found in patients with
ulcerative colitis. NOD2 has a role in apoptosis and in the recognition of microbial
endotoxins.
chromosome 16. Homozygosity for a mutation that truncates the gene increases the risk of
Crohn's disease by a factor of 20 to 40. No such mutations have been found in patients with
ulcerative colitis. NOD2 has a role in apoptosis and in the recognition of microbial
endotoxins.
NOD2, a gene conferring susceptibility to Crohn's disease, has been identified on chromosome 16. Homozygosity for a mutation that truncates the gene increases the risk of Crohn's disease by a factor of 20 to 40. No such mutations have been found in patients with ulcerative colitis. NOD2 has a role in apoptosis and in the recognition of microbial endotoxins.
The New England Journal Of Medicine