Preprothyrotropin-releasing hormone mRNA in the rat central gray is strongly and persistently induced during morphine withdrawal
LG Gahn, KA Sevarino - Neuropeptides, 1996 - Elsevier
In vivo evidence strongly implicates the central gray in expression of the physical symptoms
of opiate withdrawal. Preprothyrotropin-releasing hormone (ppTRH) mRNA is highly
expressed in the central gray. Furthermore, systemic administration of thyrotropin-releasing
hormone (TRH) inhibits the development of opiate dependence in rats. To elucidate the link
between TRH and opiate withdrawal, we examined the regulation of ppTRH mRNA in the
central gray of rats made dependent on morphine, and during opiate withdrawal, using …
of opiate withdrawal. Preprothyrotropin-releasing hormone (ppTRH) mRNA is highly
expressed in the central gray. Furthermore, systemic administration of thyrotropin-releasing
hormone (TRH) inhibits the development of opiate dependence in rats. To elucidate the link
between TRH and opiate withdrawal, we examined the regulation of ppTRH mRNA in the
central gray of rats made dependent on morphine, and during opiate withdrawal, using …