Immunohistochemical evidence for the implication of PCI in the processing of proneurotensin in rat brain
P Villeneuve, NG Seidah, A Beaudet - Neuroreport, 2000 - journals.lww.com
Biochemical studies have shown that prohormone convertases PC1, PC2 and PC5A all
have the capacity to process, with different specificities, the neurotensin/neuromedin N
precursor, pro-NT/NN. A previous study from our laboratory has demonstrated that in rat
brain, both PC2 and PC5A may be co-expressed with NT, lending support to a physiological
implication of these two enzymes in the endoproteolytic maturation of pro-NT/NN. In the
present study, we sought to determine whether PC1 might also be involved in this process …
have the capacity to process, with different specificities, the neurotensin/neuromedin N
precursor, pro-NT/NN. A previous study from our laboratory has demonstrated that in rat
brain, both PC2 and PC5A may be co-expressed with NT, lending support to a physiological
implication of these two enzymes in the endoproteolytic maturation of pro-NT/NN. In the
present study, we sought to determine whether PC1 might also be involved in this process …