Influence of the somatostatin receptor sst2 on growth factor signal cascades in human glioma cells
J Held-Feindt, F Forstreuter, T Pufe, R Mentlein - Molecular brain research, 2001 - Elsevier
The somatostatin receptor subtype sst2A is highly expressed, non-mutated and functionally
active in gliomas. After stimulation of cultivated human U343 glioma cells with somatostatin,
octreotide (sst2-, sst3-and sst5-selective peptide agonist) or the sst2-selective non-peptide
agonist L-054,522 multiple signal transduction pathways are induced: elevated cAMP levels
are reduced, protein tyrosine phosphatases (especially SHP2) are activated and mitogen-
activated protein kinases are inhibited. Stimulation of the phosphatases resulted in …
active in gliomas. After stimulation of cultivated human U343 glioma cells with somatostatin,
octreotide (sst2-, sst3-and sst5-selective peptide agonist) or the sst2-selective non-peptide
agonist L-054,522 multiple signal transduction pathways are induced: elevated cAMP levels
are reduced, protein tyrosine phosphatases (especially SHP2) are activated and mitogen-
activated protein kinases are inhibited. Stimulation of the phosphatases resulted in …