Transcription of the mouse PAC1 receptor gene: cell-specific expression and regulation by Zac1
N Rodrı́guez-Henche, F Jamen, C Leroy… - … et Biophysica Acta (BBA …, 2002 - Elsevier
Regulations of the PACAP type 1 (PAC1) receptor expression have been described in the
brain and the anterior pituitary. To understand the molecular mechanisms underlying mouse
PAC1 gene regulation, we first mapped its transcription start sites (tss). PAC1 receptor RNA
initiates from two major sites in embryos and adult tissues. Functional analysis revealed a
basal promoter within the first 180 bp upstream of transcription start. Negative regulatory
sequences upstream of this minimal promoter control the cell type-specific transcription of a …
brain and the anterior pituitary. To understand the molecular mechanisms underlying mouse
PAC1 gene regulation, we first mapped its transcription start sites (tss). PAC1 receptor RNA
initiates from two major sites in embryos and adult tissues. Functional analysis revealed a
basal promoter within the first 180 bp upstream of transcription start. Negative regulatory
sequences upstream of this minimal promoter control the cell type-specific transcription of a …