Endothelial trophic support of neuronal production and recruitment from the adult mammalian subependyma
C Leventhal, S Rafii, D Rafii, A Shahar… - Molecular and Cellular …, 1999 - Elsevier
Vascular endothelial cells are among the first cells that ventricular zone neuroblasts
encounter during early development. The ventricular zone cells promote angiogenesis by
the invading vasculature, with the release of endothelial mitogens. Yet the feedback support
of young neurons by endothelial cells (ECs) has not hitherto been explored. We therefore
asked whether ECs might participate in neuronal recruitment, by providing neurotrophic
support to newly generated neurons. We used the neurogenic subependymal zone (SZ) of …
encounter during early development. The ventricular zone cells promote angiogenesis by
the invading vasculature, with the release of endothelial mitogens. Yet the feedback support
of young neurons by endothelial cells (ECs) has not hitherto been explored. We therefore
asked whether ECs might participate in neuronal recruitment, by providing neurotrophic
support to newly generated neurons. We used the neurogenic subependymal zone (SZ) of …