Effect of indoleamine 2, 3-dioxygenase on induction of experimental autoimmune encephalomyelitis
K Sakurai, JP Zou, JR Tschetter, JM Ward… - Journal of …, 2002 - Elsevier
Experimental autoimmune encephalomyelitis (EAE) is a T cell-mediated demyelinating
disease of the central nervous system (CNS). Indoleamine 2, 3-dioxygenase (IDO) is an
enzyme that catabolizes tryptophan, which can result in the death of T lymphocytes. This
effect of IDO is inhibited by 1-methyl-tryptophan (1-MT). We used a murine model of EAE to
demonstrate:(1) opposing patterns of spinal cord IDO and interferon-γ (INF-γ) mRNA
expression through the preclinical, acute and remission I phases of EAE;(2) a change in the …
disease of the central nervous system (CNS). Indoleamine 2, 3-dioxygenase (IDO) is an
enzyme that catabolizes tryptophan, which can result in the death of T lymphocytes. This
effect of IDO is inhibited by 1-methyl-tryptophan (1-MT). We used a murine model of EAE to
demonstrate:(1) opposing patterns of spinal cord IDO and interferon-γ (INF-γ) mRNA
expression through the preclinical, acute and remission I phases of EAE;(2) a change in the …