Interferon-gamma-dependent/independent expression of indoleamine 2, 3-dioxygenase: studies with interferon-gamma-knockout mice
O Takikawa, Y Tagawa, Y Iwakura, R Yoshida… - … , and Melatonin: Basic …, 1999 - Springer
O Takikawa, Y Tagawa, Y Iwakura, R Yoshida, RJW Truscott
Tryptophan, Serotonin, and Melatonin: Basic Aspects and Applications, 1999•SpringerThe role of IFN-γ in the expression of indoleamine 2, 3-dioxygenase (IDO), a tryptophan
oxidizing enzyme, in mouse tissues under physiological and pathological conditions was
investigated using IFN-γ-knockout mice. The results revealed that i) the expression of IDO in
the large intestine or in the cecum is mediated by IFN-γ, ii) for the systemic IDO induction
under endotoxin shock, IFN-γ is a dominant inducer but not essential, and an IFN-γ-
independent mechanism is also operative, iii) the systemic induction of IDO caused by IL-12 …
oxidizing enzyme, in mouse tissues under physiological and pathological conditions was
investigated using IFN-γ-knockout mice. The results revealed that i) the expression of IDO in
the large intestine or in the cecum is mediated by IFN-γ, ii) for the systemic IDO induction
under endotoxin shock, IFN-γ is a dominant inducer but not essential, and an IFN-γ-
independent mechanism is also operative, iii) the systemic induction of IDO caused by IL-12 …
Abstract
The role of IFN-γ in the expression of indoleamine 2,3-dioxygenase (IDO), a tryptophan oxidizing enzyme, in mouse tissues under physiological and pathological conditions was investigated using IFN-γ-knockout mice. The results revealed that i) the expression of IDO in the large intestine or in the cecum is mediated by IFN-γ, ii) for the systemic IDO induction under endotoxin shock, IFN-γ is a dominant inducer but not essential, and an IFN-γ-independent mechanism is also operative, iii) the systemic induction of IDO caused by IL-12 or Pokeweed mitogen is mediated by IFN-γ, and iv) the constitutive IDO expression in the epididymis is IFN-γ-independent.
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