Decreased HDL cholesterol levels but normal lipid absorption, growth, and feeding behavior in apolipoprotein A-IV knockout mice
PH Weinstock, CL Bisgaier, T Hayek… - Journal of lipid …, 1997 - ASBMB
To determine the physiological role of apolipoprotein (apo) A-IV, knockout mice were
created by gene targeting in embryonic stem cells. In apoA-IV knockout mice, plasma
cholesterol and triglyceride levels were reduced 25% and 44%, respectively, compared with
controls. These changes were accounted for by decreased high density (HDL) and very low
density lipoprotein (VLDL) levels, respectively, and metabolic studies indicated increased
HDL-cholesteryl ester (CE) fractional catabolic rate (FCR) and reduced VLDL transport rate …
created by gene targeting in embryonic stem cells. In apoA-IV knockout mice, plasma
cholesterol and triglyceride levels were reduced 25% and 44%, respectively, compared with
controls. These changes were accounted for by decreased high density (HDL) and very low
density lipoprotein (VLDL) levels, respectively, and metabolic studies indicated increased
HDL-cholesteryl ester (CE) fractional catabolic rate (FCR) and reduced VLDL transport rate …