Novel Cd4+ and Cd8+ T–Cell Determinants Within the Ns3 Protein in Subjects With Spontaneously Resolved Hcv Infection
AM Wertheimer, C Miner, DM Lewinsohn, AW Sasaki… - Hepatology, 2003 - journals.lww.com
Spontaneous resolution of hepatitis C virus (HCV) infection is a relatively infrequent event,
and these individuals provide a unique opportunity to characterize correlates of protective
immunity as an important first step in the development of vaccine candidates. The aim of this
study was to directly and comprehensively enumerate HCV–nonstructural protein 3 (NS3)
specific CD4+ and CD8+ T cells ex vivo from HLA diverse individuals who had been
successful in spontaneously resolving HCV infection. We measured interferon gamma (IFN …
and these individuals provide a unique opportunity to characterize correlates of protective
immunity as an important first step in the development of vaccine candidates. The aim of this
study was to directly and comprehensively enumerate HCV–nonstructural protein 3 (NS3)
specific CD4+ and CD8+ T cells ex vivo from HLA diverse individuals who had been
successful in spontaneously resolving HCV infection. We measured interferon gamma (IFN …