Uncoupling protein-2 (UCP2) is present in many tissues with relevance to fuel metabolism,
and its expression is increased in fat and muscle in response to elevated circulating free
fatty acids resulting from fasting and high fat feeding. We proposed a role for peroxisome
proliferator-activated receptor-γ (PPARγ) as a mediator of these physiological changes in
UCP2, because thiazolidinediones also increase expression of UCP2 in these cell types (1).
To determine the molecular basis for this regulation, we isolated the 7.3-kilobase promoter …