[HTML][HTML] Mammalian AMP-activated protein kinase subfamily (∗)
D Stapleton, KI Mitchelhill, G Gao, J Widmer… - Journal of Biological …, 1996 - ASBMB
The mammalian 5′-AMP-activated protein kinase (AMPK) is related to a growing family of
protein kinases in yeast and plants that are regulated by nutritional stress. We find the most
prominent expressed form of the hepatic AMPK catalytic subunit (α 1) is distinct from the
previously cloned kinase subunit (α 2). The α 1 (548 residues) and α 2 (552 residues)
isoforms have 90% amino acid sequence identity within the catalytic core but only 61%
identity elsewhere. The tissue distribution of the AMPK activity most closely parallels the low …
protein kinases in yeast and plants that are regulated by nutritional stress. We find the most
prominent expressed form of the hepatic AMPK catalytic subunit (α 1) is distinct from the
previously cloned kinase subunit (α 2). The α 1 (548 residues) and α 2 (552 residues)
isoforms have 90% amino acid sequence identity within the catalytic core but only 61%
identity elsewhere. The tissue distribution of the AMPK activity most closely parallels the low …