[HTML][HTML] Important role of phosphodiesterase 3B for the stimulatory action of cAMP on pancreatic β-cell exocytosis and release of insulin
L Härndahl, XJ Jing, R Ivarsson, E Degerman… - Journal of Biological …, 2002 - ASBMB
Cyclic AMP potentiates glucose-stimulated insulin release and mediates the stimulatory
effects of hormones such as glucagon-like peptide 1 (GLP-1) on pancreatic β-cells. By
inhibition of cAMP-degrading phosphodiesterase (PDE) and, in particular, selective
inhibition of PDE3 activity, stimulatory effects on insulin secretion have been observed.
Molecular and functional information on β-cell PDE3 is, however, scarce. To provide such
information, we have studied the specific effects of the PDE3B isoform by adenovirus …
effects of hormones such as glucagon-like peptide 1 (GLP-1) on pancreatic β-cells. By
inhibition of cAMP-degrading phosphodiesterase (PDE) and, in particular, selective
inhibition of PDE3 activity, stimulatory effects on insulin secretion have been observed.
Molecular and functional information on β-cell PDE3 is, however, scarce. To provide such
information, we have studied the specific effects of the PDE3B isoform by adenovirus …