Characteristics of skeletal muscle in mdx mutant mice
S De La Porte, S Morin, J Koenig - International review of cytology, 1999 - Elsevier
We review the extensive research conducted on the mdx mouse since 1987, when
demonstration of the absence of dystrophin in mdx muscle led to X-chromosome-linked
muscular dystrophy (mdx) being considered as a homolog of Duchenne muscular dystrophy.
Certain results are contradictory. We consider most aspects of mdx skeletal muscle:(i) the
distribution and roles of dystrophin, utrophin, and associated proteins;(ii) morphological
characteristics of the skeletal muscle and hypotheses put forward to explain the …
demonstration of the absence of dystrophin in mdx muscle led to X-chromosome-linked
muscular dystrophy (mdx) being considered as a homolog of Duchenne muscular dystrophy.
Certain results are contradictory. We consider most aspects of mdx skeletal muscle:(i) the
distribution and roles of dystrophin, utrophin, and associated proteins;(ii) morphological
characteristics of the skeletal muscle and hypotheses put forward to explain the …