Ablation of peroxisome proliferator activated receptor (PPAR) α, a lipid-activated
transcription factor that regulates expression of β-oxidative genes, results in profound
metabolic abnormalities in liver and heart. In the present study we used PPARα knockout
(KO) mice to determine whether this transcription factor is essential for regulating fuel
metabolism in skeletal muscle. When animals were challenged with exhaustive exercise or
starvation, KO mice exhibited lower serum levels of glucose, lactate, and ketones and higher …