Central LIF gene therapy suppresses food intake, body weight, serum leptin and insulin for extended periods
E Beretta, H Dhillon, PS Kalra, SP Kalra - Peptides, 2002 - Elsevier
Leukemia inhibitory factor (LIF) overexpression, induced by the intracerebroventricular (icv)
injection of an recombinant adeno-associated viral vector encoding LIF (rAAV–LIF), resulted
in a dose-dependent reduction in body weight (BW) gain, food intake (FI) and adiposity,
evidenced by suppression of serum leptin and free fatty acids for an extended period in
outbred adult female rats. A dose-dependent reduction in serum insulin levels and
unchanged serum glucose, energy expenditure through thermogenesis as indicated by …
injection of an recombinant adeno-associated viral vector encoding LIF (rAAV–LIF), resulted
in a dose-dependent reduction in body weight (BW) gain, food intake (FI) and adiposity,
evidenced by suppression of serum leptin and free fatty acids for an extended period in
outbred adult female rats. A dose-dependent reduction in serum insulin levels and
unchanged serum glucose, energy expenditure through thermogenesis as indicated by …