Interleukin-6 as a central mediator of cardiovascular risk associated with chronic inflammation, smoking, diabetes, and visceral obesity: down-regulation with essential …
MF McCarty - Medical hypotheses, 1999 - Elsevier
Increased plasma levels of fibrinogen and C-reactive protein (CRP), as well as leukocytosis,
are now established as risk factors for the thromboembolic complications of vascular
disease. Chronic inflammation or infection associated with an acute-phase response–
notably, periodontal disease and smoking-induced lung damage–are likewise known to
increase cardiovascular risk. A common etiologic factor in these conditions may be
interleukin-6 (IL-6), acting on hepatocytes to induce acute-phase reactants that increase …
are now established as risk factors for the thromboembolic complications of vascular
disease. Chronic inflammation or infection associated with an acute-phase response–
notably, periodontal disease and smoking-induced lung damage–are likewise known to
increase cardiovascular risk. A common etiologic factor in these conditions may be
interleukin-6 (IL-6), acting on hepatocytes to induce acute-phase reactants that increase …