Hematopoietic stem cells contribute to the regeneration of renal tubules after renal ischemia-reperfusion injury in mice

F Lin, K Cordes, L Li, L Hood, WG Couser… - Journal of the …, 2003 - journals.lww.com
Ischemia-reperfusion injury (I/R injury) is a common cause of acute renal failure. Recovery
from I/R injury requires renal tubular regeneration. Hematopoietic stem cells (HSC) have
been shown to be capable of differentiating into hepatocytes, cardiac myocytes,
gastrointestinal epithelial cells, and vascular endothelial cells during tissue repair. The
current study tested the hypothesis that murine HSC can contribute to the regeneration of
renal tubular epithelial cells after I/R injury. HSC isolated from male Rosa26 mice that …