Ischemia remains the primary cause of acute renal fail-ure in adults. Following the
development and practical application of dialysis, little progress has been made in the
treatment of ischemic acute renal failure (ARF) to significantly affect patient outcome.
However, excellent advancement has occurred in the understanding of the cellular
consequences of ischemic injury. This has occurred through an integrated approach using
complementary in vivo and in vitro models of ischemic cell injury. Fundamental insights into …