[HTML][HTML] Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling
A Pezet, H Favre, PA Kelly, M Edery - Journal of Biological Chemistry, 1999 - ASBMB
Prolactin (PRL) has been shown to activate the cytoplasmic tyrosine kinase Janus kinase 2
(Jak2) and the subsequent recruitment of various signaling molecules including members of
the signal transducer and activator of transcription family of transcription factors. Recently,
an expanding family of cytokine-inducible inhibitors of signaling has been identified that
initially included four members: suppressor of cytokine signaling (SOCS)-1, SOCS-2, SOCS-
3, and cytokine-inducible src homology domain 2 (SH-2) proteins. The present study …
(Jak2) and the subsequent recruitment of various signaling molecules including members of
the signal transducer and activator of transcription family of transcription factors. Recently,
an expanding family of cytokine-inducible inhibitors of signaling has been identified that
initially included four members: suppressor of cytokine signaling (SOCS)-1, SOCS-2, SOCS-
3, and cytokine-inducible src homology domain 2 (SH-2) proteins. The present study …