Cytokine promoter gene polymorphisms and idiopathic recurrent pregnancy loss
SJ Babbage, PD Arkwright, GS Vince, C Perrey… - Journal of reproductive …, 2001 - Elsevier
Approximately one in 300 women experience recurrent pregnancy loss (RPL), the aetiology
of which is unknown in at least 40% of cases. Previously, some studies have shown
increased production of pro-inflammatory cytokines (tumour necrosis factor-α and interferon-
γ) and reduced production of anti-inflammatory cytokines (interleukin-10) by circulating
blood lymphocytes isolated from these patients when compared with controls. The reasons
for this are unclear. The production of these cytokines are partly under genetic control. This …
of which is unknown in at least 40% of cases. Previously, some studies have shown
increased production of pro-inflammatory cytokines (tumour necrosis factor-α and interferon-
γ) and reduced production of anti-inflammatory cytokines (interleukin-10) by circulating
blood lymphocytes isolated from these patients when compared with controls. The reasons
for this are unclear. The production of these cytokines are partly under genetic control. This …