Does properdin crosslink the cellular and the humoral immune response?
WJ Schwaeble, KBM Reid - Immunology today, 1999 - cell.com
WJ Schwaeble, KBM Reid
Immunology today, 1999•cell.comProperdin, the only known positive regulator of complement activation, is produced by cells
of the monocyte–macrophage, T-cell and granulocyte lineages. Complement activation
products have an established role in the cellular immune response. However, here, Wilhelm
Schwaeble and Kenneth Reid discuss current data demonstrating that leukocytes form a
positive feedback loop of activation by properdin release.
of the monocyte–macrophage, T-cell and granulocyte lineages. Complement activation
products have an established role in the cellular immune response. However, here, Wilhelm
Schwaeble and Kenneth Reid discuss current data demonstrating that leukocytes form a
positive feedback loop of activation by properdin release.
Abstract
Properdin, the only known positive regulator of complement activation, is produced by cells of the monocyte–macrophage, T-cell and granulocyte lineages. Complement activation products have an established role in the cellular immune response. However, here, Wilhelm Schwaeble and Kenneth Reid discuss current data demonstrating that leukocytes form a positive feedback loop of activation by properdin release.
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