Development of lipofuscin-like fluorescence in the retinal pigment epithelium in response to protease inhibitor treatment
ML Katz, MJ Shanker - Mechanisms of ageing and development, 1989 - Elsevier
Experiments were conducted to determine whether photoreceptor outer segement
components contain precursors for lipofuscin fluorophores that accumulate in the retinal
pigment epithelium (RPE) during senescence. Intravitreal injection of the lysosomal
protease inhibitor leupeptin caused a rapid accumulation of inclusions with lipofuscin-like
autofluorescence in the RPE of albino rats. These inclusions appeared to be derived from
photoreceptor outer segments, which are normally phagocytosed and degraded by the RPE …
components contain precursors for lipofuscin fluorophores that accumulate in the retinal
pigment epithelium (RPE) during senescence. Intravitreal injection of the lysosomal
protease inhibitor leupeptin caused a rapid accumulation of inclusions with lipofuscin-like
autofluorescence in the RPE of albino rats. These inclusions appeared to be derived from
photoreceptor outer segments, which are normally phagocytosed and degraded by the RPE …