Activated caspase-3 expression in Alzheimer's and aged control brain: correlation with Alzheimer pathology
JH Su, M Zhao, AJ Anderson, A Srinivasan… - Brain research, 2001 - Elsevier
JH Su, M Zhao, AJ Anderson, A Srinivasan, CW Cotman
Brain research, 2001•ElsevierSeveral studies have suggested that activated caspase-3 has properties of a cell death
executioner protease. In this study, we examined the expression of activated caspase-3 in
AD and aged control brains. Activated caspase-3 immunoreactivity was seen in neurons,
astrocytes, and blood vessels, was elevated in AD, and exhibited a high degree of
colocalization with neurofibrillary tangles and senile plaques. These data suggest that
activated caspase-3 may be a factor in functional decline and may have an important role in …
executioner protease. In this study, we examined the expression of activated caspase-3 in
AD and aged control brains. Activated caspase-3 immunoreactivity was seen in neurons,
astrocytes, and blood vessels, was elevated in AD, and exhibited a high degree of
colocalization with neurofibrillary tangles and senile plaques. These data suggest that
activated caspase-3 may be a factor in functional decline and may have an important role in …
Several studies have suggested that activated caspase-3 has properties of a cell death executioner protease. In this study, we examined the expression of activated caspase-3 in AD and aged control brains. Activated caspase-3 immunoreactivity was seen in neurons, astrocytes, and blood vessels, was elevated in AD, and exhibited a high degree of colocalization with neurofibrillary tangles and senile plaques. These data suggest that activated caspase-3 may be a factor in functional decline and may have an important role in neuronal cell death and plaque formation in AD brain.
Elsevier