Pulmonary vascular effects of a fibrin (ogen)-derived vasoactive peptide
DF Kern, K Saldeen, T Saldeen, AB Malik - Thrombosis research, 1986 - Elsevier
We examined the effects of the 5 amino acid fibrin (ogen)-degradation product Ala-Arg-Pro-
Ala-Lys (Peptide 6A) on pulmonary hemodynamics and vascular permeability in the isolated-
perfused guinea pig lung. Infusion of this peptide (100 p moles) resulted in a small increase
in pulmonary vascular resistance. The pulmonary vasoconstrictor response was not
mediated by histamine or cyclooxygenase metabolites since neither H1 blockers nor
meclofenamate inhibited the response. The capillary filtration coefficient (a measure of water …
Ala-Lys (Peptide 6A) on pulmonary hemodynamics and vascular permeability in the isolated-
perfused guinea pig lung. Infusion of this peptide (100 p moles) resulted in a small increase
in pulmonary vascular resistance. The pulmonary vasoconstrictor response was not
mediated by histamine or cyclooxygenase metabolites since neither H1 blockers nor
meclofenamate inhibited the response. The capillary filtration coefficient (a measure of water …