Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless
H Min, DM Danilenko, SA Scully, B Bolon… - Genes & …, 1998 - genesdev.cshlp.org
H Min, DM Danilenko, SA Scully, B Bolon, BD Ring, JE Tarpley, M DeRose, WS Simonet
Genes & development, 1998•genesdev.cshlp.orgFgf-10-deficient mice (Fgf-10−/−) were generated to determine the role (s) of Fgf-10 in
vertebrate development. Limb bud initiation was abolished in Fgf-10−/− mice. Strikingly, Fgf-
10−/− fetuses continued to develop until birth, despite the complete absence of both fore-
and hindlimbs. Fgf-10 is necessary for apical ectodermal ridge (AER) formation and acts
epistatically upstream of Fgf-8, the earliest known AER marker in mice. Fgf-10−/− mice
exhibited perinatal lethality associated with complete absence of lungs. Although tracheal …
vertebrate development. Limb bud initiation was abolished in Fgf-10−/− mice. Strikingly, Fgf-
10−/− fetuses continued to develop until birth, despite the complete absence of both fore-
and hindlimbs. Fgf-10 is necessary for apical ectodermal ridge (AER) formation and acts
epistatically upstream of Fgf-8, the earliest known AER marker in mice. Fgf-10−/− mice
exhibited perinatal lethality associated with complete absence of lungs. Although tracheal …
Fgf-10-deficient mice (Fgf-10−/− ) were generated to determine the role(s) of Fgf-10 in vertebrate development. Limb bud initiation was abolished inFgf-10−/− mice. Strikingly,Fgf-10−/− fetuses continued to develop until birth, despite the complete absence of both fore- and hindlimbs. Fgf-10 is necessary for apical ectodermal ridge (AER) formation and acts epistatically upstream of Fgf-8, the earliest known AER marker in mice.Fgf-10−/− mice exhibited perinatal lethality associated with complete absence of lungs. Although tracheal development was normal, main-stem bronchial formation, as well as all subsequent pulmonary branching morphogenesis, was completely disrupted. The pulmonary phenotype ofFgf-10−/− mice is strikingly similar to that of the Drosophila mutant branchless, anFgf homolog.
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