Psoriasis vulgaris is the most prevalent T-cell-mediated inflammatory disease in humans.
The pathogenesis of psoriasis is linked to activation of several types of leukocytes that
control cellular immunity and to a T-cell-dependent inflammatory process in skin that
accelerates the growth of epidermal and vascular cells in psoriasis lesions. Critical steps in
immunologic activation include Langerhans cell maturation (activation), T-cell activation,
differentiation and expansion of type 1 T cells, selective trafficking of activated T cells to skin …