Atherosclerosis and diabetes: the RAGE connection
AM Schmidt, D Stern - Current atherosclerosis reports, 2000 - Springer
AM Schmidt, D Stern
Current atherosclerosis reports, 2000•SpringerDiabetes mellitus begins as a disorder of glucose metabolism that progressively
compromises the function of virtually every organ system as the secondary complications
inexorably develop. The quality of life for patients with diabetes is diminished by the
consequences of these complications. Accelerated and aggressive atherosclerosis is the
greatest cause of morbidity and mortality with diabetes, emphasizing the importance of
determining underlying mechanisms. This review highlights the role of the multiligand …
compromises the function of virtually every organ system as the secondary complications
inexorably develop. The quality of life for patients with diabetes is diminished by the
consequences of these complications. Accelerated and aggressive atherosclerosis is the
greatest cause of morbidity and mortality with diabetes, emphasizing the importance of
determining underlying mechanisms. This review highlights the role of the multiligand …
Abstract
Diabetes mellitus begins as a disorder of glucose metabolism that progressively compromises the function of virtually every organ system as the secondary complications inexorably develop. The quality of life for patients with diabetes is diminished by the consequences of these complications. Accelerated and aggressive atherosclerosis is the greatest cause of morbidity and mortality with diabetes, emphasizing the importance of determining underlying mechanisms. This review highlights the role of the multiligand receptor for advanced glycation endproducts (RAGE) and two of its ligands, advanced glycation endproducts (AGEs) and S100/calgranulins, in the pathogenesis of atherosclerosis associated with diabetes. The results of the studies reviewed herein suggest that RAGE is a potential therapeutic target for macrovascular disease in diabetes.
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