Regulation of Antigen-Specific CD8+ T Cell Homeostasis by Perforin and Interferon-γ
VP Badovinac, AR Tvinnereim, JT Harty - Science, 2000 - science.org
VP Badovinac, AR Tvinnereim, JT Harty
Science, 2000•science.orgT cell memory depends on factors that regulate expansion and death of these cells after
antigenic stimulation. Mice deficient in perforin and interferon-γ (IFN-γ) exhibited increased
expansion, altered immunodominance, and decreased death of antigen-specific CD8+ T
cells after infection with an attenuated strain of Listeria monocytogenes, which was cleared
from these mice. Expansion of CD8+ T cells was controlled by perforin, whereas IFN-γ
regulated immunodominance and the death phase. Thus, perforin and IFN-γ regulate …
antigenic stimulation. Mice deficient in perforin and interferon-γ (IFN-γ) exhibited increased
expansion, altered immunodominance, and decreased death of antigen-specific CD8+ T
cells after infection with an attenuated strain of Listeria monocytogenes, which was cleared
from these mice. Expansion of CD8+ T cells was controlled by perforin, whereas IFN-γ
regulated immunodominance and the death phase. Thus, perforin and IFN-γ regulate …
T cell memory depends on factors that regulate expansion and death of these cells after antigenic stimulation. Mice deficient in perforin and interferon-γ (IFN-γ) exhibited increased expansion, altered immunodominance, and decreased death of antigen-specific CD8+ T cells after infection with an attenuated strain ofListeria monocytogenes, which was cleared from these mice. Expansion of CD8+ T cells was controlled by perforin, whereas IFN-γ regulated immunodominance and the death phase. Thus, perforin and IFN-γ regulate distinct elements of CD8+ T cell homeostasis independently of their role as antimicrobial effector molecules.
AAAS