The regulation of AP-1 activity by mitogen-activated protein kinases
M Karin, CJ Marshall - … of the Royal Society of London …, 1996 - royalsocietypublishing.org
M Karin, CJ Marshall
Philosophical Transactions of the Royal Society of London …, 1996•royalsocietypublishing.orgAP-1 is a collection of dimeric sequence specific, DNA binding, transcriptional activators
composed of Jun and Fos subunits. The composition, the level and the activity of AP-1
complexes are regulated in response to extracellular stimuli. An important role in this
regulation is played by mitogen-activated protein kinases (MAPKs). The specific roles of
three MAPKs, namely ERK, JNK and FRK, in modulation of both the level and activity of AP-
1, are discussed.
composed of Jun and Fos subunits. The composition, the level and the activity of AP-1
complexes are regulated in response to extracellular stimuli. An important role in this
regulation is played by mitogen-activated protein kinases (MAPKs). The specific roles of
three MAPKs, namely ERK, JNK and FRK, in modulation of both the level and activity of AP-
1, are discussed.
AP-1 is a collection of dimeric sequence specific, DNA binding, transcriptional activators composed of Jun and Fos subunits. The composition, the level and the activity of AP-1 complexes are regulated in response to extracellular stimuli. An important role in this regulation is played by mitogen-activated protein kinases (MAPKs). The specific roles of three MAPKs, namely ERK, JNK and FRK, in modulation of both the level and activity of AP-1, are discussed.
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