Regulation of NF-κB activation by MAP kinase cascades
K Schulze-Osthoff, D Ferrari, K Riehemann… - Immunobiology, 1997 - Elsevier
Transcription factor NF-κB plays a crucial role in the regulation of numerous genes involved
inthe inflammatory response and control of cell death. Activation of NF-κB is mediated
through the phosphorylation of its inhibitory subunit IκB, followed by the subsequent
degradation of IκB at the proteasome. A second level of control involves phosphorylation
events of NF-κB in the cell nucleus. The kinases that regulate these processes are rather
undefined. NF-κB activation is induced by a great variety of predominantly pathogenic and …
inthe inflammatory response and control of cell death. Activation of NF-κB is mediated
through the phosphorylation of its inhibitory subunit IκB, followed by the subsequent
degradation of IκB at the proteasome. A second level of control involves phosphorylation
events of NF-κB in the cell nucleus. The kinases that regulate these processes are rather
undefined. NF-κB activation is induced by a great variety of predominantly pathogenic and …