[HTML][HTML] Stimulation of “stress-regulated” mitogen-activated protein kinases (stress-activated protein kinases/c-Jun N-terminal kinases and p38-mitogen-activated …
A Clerk, SJ Fuller, A Michael, PH Sugden - Journal of Biological Chemistry, 1998 - ASBMB
" Stress-regulated" mitogen-activated protein kinases (SR-MAPKs) comprise the stress-
activated protein kinases (SAPKs)/c-Jun N-terminal kinases (JNKs) and the p38-MAPKs. In
the perfused heart, ischemia/reperfusion activates SR-MAPKs. Although the agent (s)
directly responsible is unclear, reactive oxygen species are generated during
ischemia/reperfusion. We have assessed the ability of oxidative stress (as exemplified by H
2 O 2) to activate SR-MAPKs in the perfused heart and compared it with the effect of …
activated protein kinases (SAPKs)/c-Jun N-terminal kinases (JNKs) and the p38-MAPKs. In
the perfused heart, ischemia/reperfusion activates SR-MAPKs. Although the agent (s)
directly responsible is unclear, reactive oxygen species are generated during
ischemia/reperfusion. We have assessed the ability of oxidative stress (as exemplified by H
2 O 2) to activate SR-MAPKs in the perfused heart and compared it with the effect of …