[HTML][HTML] Identification of a novel recognition sequence for integrin αMβ2 within the γ-chain of fibrinogen
TP Ugarova, DA Solovjov, L Zhang, DI Loukinov… - Journal of Biological …, 1998 - ASBMB
The interaction of leukocyte integrin α M β 2 (CD11b/CD18, Mac-1) with fibrinogen has been
implicated in the inflammatory response by contributing to leukocyte adhesion to the
endothelium and subsequent transmigration. Previously, it has been demonstrated that a
peptide, P1, corresponding to residues 190–202 in the γ-chain of fibrinogen, binds to α M β
2 and blocks the interaction of fibrinogen with the receptor and that Asp 199 within P1 is
important to activity. We have demonstrated, however, that a double mutation of Asp 199-Gly …
implicated in the inflammatory response by contributing to leukocyte adhesion to the
endothelium and subsequent transmigration. Previously, it has been demonstrated that a
peptide, P1, corresponding to residues 190–202 in the γ-chain of fibrinogen, binds to α M β
2 and blocks the interaction of fibrinogen with the receptor and that Asp 199 within P1 is
important to activity. We have demonstrated, however, that a double mutation of Asp 199-Gly …