Passive transfer of autoantibodies from a patient with mutilating epidermolysis bullosa acquisita induces specific alterations in the skin of neonatal mice
L Borradori, JB Caldwell, RA Briggaman… - Archives of …, 1995 - jamanetwork.com
Background: Epidermolysis bullosa acquisita is a sub-epidermal bullous disease
characterized by IgG autoantibodies directed against type VII collagen in anchoring fibrils.
These autoantibodies are believed to play an important role in the pathogenesis of sub—
lamina densa blister formation in this disease. Observations: We describe a patient with
epidermolysis bullosa acquisita who has developed mutilating acral involvement with early
syndactyly and extensive scarring lesions of the scalp. The patient's serum contains IgG …
characterized by IgG autoantibodies directed against type VII collagen in anchoring fibrils.
These autoantibodies are believed to play an important role in the pathogenesis of sub—
lamina densa blister formation in this disease. Observations: We describe a patient with
epidermolysis bullosa acquisita who has developed mutilating acral involvement with early
syndactyly and extensive scarring lesions of the scalp. The patient's serum contains IgG …