[HTML][HTML] Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex: transfer from CD14 to TLR4 and MD-2
J da Silva Correia, K Soldau, U Christen… - Journal of Biological …, 2001 - ASBMB
The structural features of some proteins of the innate immune system involved in mediating
responses to microbial pathogens are highly conserved throughout evolution. Examples
include members of the Drosophila Toll (dToll) and the mammalian Toll-like receptor (TLR)
protein families. Activation ofDrosophila Toll is believed to occur via an endogenous peptide
rather than through direct binding of microbial products to the Toll protein. In mammals there
is a growing consensus that lipopolysaccharide (LPS) initiates its biological activities …
responses to microbial pathogens are highly conserved throughout evolution. Examples
include members of the Drosophila Toll (dToll) and the mammalian Toll-like receptor (TLR)
protein families. Activation ofDrosophila Toll is believed to occur via an endogenous peptide
rather than through direct binding of microbial products to the Toll protein. In mammals there
is a growing consensus that lipopolysaccharide (LPS) initiates its biological activities …