Flotillin-1 was recently shown to be enriched on detergent-resistant domains of the plasma
membrane called lipid rafts. These rafts, enriched in sphingolipids and cholesterol,
sequester certain proteins while excluding others. Lipid rafts have been implicated in
numerous cellular processes including signal transduction, membrane trafficking, and
molecular sorting. In this study, we demonstrate both morphologically and biochemically that
lipid rafts are present on phagosomes. These structures are enriched in flotillin-1 and devoid …