[HTML][HTML] Cellular recognition of tri-/di-palmitoylated peptides is independent from a domain encompassing the N-terminal seven leucine-rich repeat (LRR)/LRR-like …
Toll-like receptors (TLRs) mediate microbial pattern recognition in vertebrates. A broad
variety of agonists has been attributed to TLR2 and three TLRs, TLR4, TLR2, and TLR5,
have been demonstrated to bind microbial products. Distinct agonists might interact with
different subdomains of the TLR2 extracellular domain. The TLR2 extracellular domain
sequence includes 10 canonical leucine-rich repeat (LRR) motifs and 8–10 additional and
potentially functionally relevant LRR-like motifs. Thus, the transfection of TLR2 LRR/LRR …
variety of agonists has been attributed to TLR2 and three TLRs, TLR4, TLR2, and TLR5,
have been demonstrated to bind microbial products. Distinct agonists might interact with
different subdomains of the TLR2 extracellular domain. The TLR2 extracellular domain
sequence includes 10 canonical leucine-rich repeat (LRR) motifs and 8–10 additional and
potentially functionally relevant LRR-like motifs. Thus, the transfection of TLR2 LRR/LRR …