[HTML][HTML] Extracellular Toll-Like Receptor 2 Region Containing Ser40-Ile64 but Not Cys30-Ser39 Is Critical for the Recognition ofStaphylococcus aureus Peptidoglycan
H Mitsuzawa, I Wada, H Sano, D Iwaki… - Journal of Biological …, 2001 - ASBMB
Toll-like receptor 2 (TLR2) and CD14 function as pattern recognition receptors for bacterial
peptidoglycan (PGN). TLRs and CD14 possess repeats of the leucine-rich motif. To address
the role of the extracellular domain of TLR2 in PGN signaling, we constructed CD14/TLR2
chimeras, in which residues 1–356 or 1–323 of CD14 were substituted for the extracellular
domain of TLR2, and five deletion mutants of TLR2, in which the progressively longer
regions of extracellular TLR2 regions were deleted. PGN induced NF-κB activation in …
peptidoglycan (PGN). TLRs and CD14 possess repeats of the leucine-rich motif. To address
the role of the extracellular domain of TLR2 in PGN signaling, we constructed CD14/TLR2
chimeras, in which residues 1–356 or 1–323 of CD14 were substituted for the extracellular
domain of TLR2, and five deletion mutants of TLR2, in which the progressively longer
regions of extracellular TLR2 regions were deleted. PGN induced NF-κB activation in …