Differential Contribution of Toll-Like Receptors 4 and 2 to the Cytokine Response to Salmonella enterica Serovar Typhimurium and Staphylococcus aureus in Mice
A Lembo, C Kalis, CJ Kirschning, V Mitolo… - Infection and …, 2003 - Am Soc Microbiol
A Lembo, C Kalis, CJ Kirschning, V Mitolo, E Jirillo, H Wagner, C Galanos, MA Freudenberg
Infection and immunity, 2003•Am Soc MicrobiolThe contribution of murine Toll-like receptors 2 and 4 (TLR2 and-4, respectively) to cytokine
induction by heat-killed bacteria was analyzed in vitro and in vivo. Gram-negative bacteria
induced cytokines primarily via TLR4; the contribution of TLR2 was only minor. Neither TLR4
nor, surprisingly, TLR2 was required in the MyD88-dependent response to Staphylococcus
aureus.
induction by heat-killed bacteria was analyzed in vitro and in vivo. Gram-negative bacteria
induced cytokines primarily via TLR4; the contribution of TLR2 was only minor. Neither TLR4
nor, surprisingly, TLR2 was required in the MyD88-dependent response to Staphylococcus
aureus.
Abstract
The contribution of murine Toll-like receptors 2 and 4 (TLR2 and -4, respectively) to cytokine induction by heat-killed bacteria was analyzed in vitro and in vivo. Gram-negative bacteria induced cytokines primarily via TLR4; the contribution of TLR2 was only minor. Neither TLR4 nor, surprisingly, TLR2 was required in the MyD88-dependent response to Staphylococcus aureus.
American Society for Microbiology