Secreted form of β-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices
A Ishida, K Furukawa, JN Keller, MP Mattson - Neuroreport, 1997 - journals.lww.com
THE secreted form of β-amyloid precursor protein (sAPPα) is released from neurons in an
activity-dependent manner, and has been reported to modulate neuronal excitability in
dissociated hippocampal neurons. We now report that sAPPα shifts the frequency
dependence for induction of long-term depression of synaptic transmission (LTD) in
hippocampal slices from adult rats. Whereas low frequency stimulation (1 Hz) of Schaffer
collateral axons induced LTD of the post synaptic response of CA1 neurons in control slices …
activity-dependent manner, and has been reported to modulate neuronal excitability in
dissociated hippocampal neurons. We now report that sAPPα shifts the frequency
dependence for induction of long-term depression of synaptic transmission (LTD) in
hippocampal slices from adult rats. Whereas low frequency stimulation (1 Hz) of Schaffer
collateral axons induced LTD of the post synaptic response of CA1 neurons in control slices …