[HTML][HTML] Signaling events in amyloid β-peptide-induced neuronal death and insulin-like growth factor I protection
W Wei, X Wang, JW Kusiak - Journal of Biological Chemistry, 2002 - ASBMB
Amyloid β-peptide (Aβ) is implicated as the toxic agent in Alzheimer's disease and is the
major component of brain amyloid plaques. In vitro, Aβ causes cell death, but the molecular
mechanisms are unclear. We analyzed the early signaling mechanisms involved in Aβ
toxicity using the SH-SY5Y neuroblastoma cell line. Aβ caused cell death and induced a 2-to
3-fold activation of JNK. JNK activation and cell death were inhibited by overexpression of a
dominant-negative SEK1 (SEK1-AL) construct. Butyrolactone I, a cdk5 inhibitor, had an …
major component of brain amyloid plaques. In vitro, Aβ causes cell death, but the molecular
mechanisms are unclear. We analyzed the early signaling mechanisms involved in Aβ
toxicity using the SH-SY5Y neuroblastoma cell line. Aβ caused cell death and induced a 2-to
3-fold activation of JNK. JNK activation and cell death were inhibited by overexpression of a
dominant-negative SEK1 (SEK1-AL) construct. Butyrolactone I, a cdk5 inhibitor, had an …