Matrix metalloproteinases, tumor necrosis factor and multiple sclerosis: an overview
S Chandler, KM Miller, JM Clements, J Lury… - Journal of …, 1997 - Elsevier
The matrix metalloproteinases (MMPs) are a family of at least 14 zinc-dependent enzymes
which are known to degrade the protein components of extracellular matrix. In adddition,
MMPs and related enzymes can also process a number of cell surface cytokines, receptors,
and other soluble proteins. In particular we have shown that the release of the pro-
inflammatory cytokine, tumor necrosis factor-α, from its membrane-bound precursor is an
MMP-dependent process. MMPs are expressed by the inflammatory cells which are …
which are known to degrade the protein components of extracellular matrix. In adddition,
MMPs and related enzymes can also process a number of cell surface cytokines, receptors,
and other soluble proteins. In particular we have shown that the release of the pro-
inflammatory cytokine, tumor necrosis factor-α, from its membrane-bound precursor is an
MMP-dependent process. MMPs are expressed by the inflammatory cells which are …