[HTML][HTML] Metalloproteinases in biology and pathology of the nervous system
Nature Reviews Neuroscience, 2001•nature.com
Matrix metalloproteinases (MMPs) have been implicated in several diseases of the nervous
system. Here we review the evidence that supports this idea and discuss the possible
mechanisms of MMP action. We then consider some of the beneficial functions of MMPs
during neural development and speculate on their roles in repair after brain injury. We also
introduce a family of proteins known as ADAMs (a disintegrin and metalloproteinase), as
some of the properties previously ascribed to MMPs are possibly the result of ADAM activity.
system. Here we review the evidence that supports this idea and discuss the possible
mechanisms of MMP action. We then consider some of the beneficial functions of MMPs
during neural development and speculate on their roles in repair after brain injury. We also
introduce a family of proteins known as ADAMs (a disintegrin and metalloproteinase), as
some of the properties previously ascribed to MMPs are possibly the result of ADAM activity.
Abstract
Matrix metalloproteinases (MMPs) have been implicated in several diseases of the nervous system. Here we review the evidence that supports this idea and discuss the possible mechanisms of MMP action. We then consider some of the beneficial functions of MMPs during neural development and speculate on their roles in repair after brain injury. We also introduce a family of proteins known as ADAMs (a disintegrin and metalloproteinase), as some of the properties previously ascribed to MMPs are possibly the result of ADAM activity.
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