Age-related working memory impairment is correlated with increases in the L-type calcium channel protein α1D (Cav1. 3) in area CA1 of the hippocampus and both …
LM Veng, MH Mesches, MD Browning - Molecular Brain Research, 2003 - Elsevier
The hippocampus is critical for spatial memory formation in rodents. Calcium currents
through L-type voltage-sensitive calcium channels (L-VSCCs) are increased in CA1 neurons
of the hippocampus of aged rats. We have recently shown that expression of the calcium
conducting L-VSCC subunit α1D (Cav1. 3) is selectively increased in area CA1 of aged rats.
We and others have speculated that excessive Ca2+ influx through L-VSCC may be
detrimental to memory formation. Therefore, we investigated the relationship between age …
through L-type voltage-sensitive calcium channels (L-VSCCs) are increased in CA1 neurons
of the hippocampus of aged rats. We have recently shown that expression of the calcium
conducting L-VSCC subunit α1D (Cav1. 3) is selectively increased in area CA1 of aged rats.
We and others have speculated that excessive Ca2+ influx through L-VSCC may be
detrimental to memory formation. Therefore, we investigated the relationship between age …