[HTML][HTML] α1D (Cav1. 3) subunits can form L-type Ca2+ channels activating at negative voltages
A Koschak, D Reimer, I Huber, M Grabner… - Journal of Biological …, 2001 - ASBMB
In cochlea inner hair cells (IHCs), L-type Ca 2+ channels (LTCCs) formed by α1D subunits
(D-LTCCs) possess biophysical and pharmacological properties distinct from those of α1C
containing C-LTCCs. We investigated to which extent these differences are determined by
α1D itself by analyzing the biophysical and pharmacological properties of cloned human
α1D splice variants in tsA-201 cells. Variant α1D 8A, containing exon 8A sequence in repeat
I, yielded α1D protein and L-type currents, whereas no intact protein and currents were …
(D-LTCCs) possess biophysical and pharmacological properties distinct from those of α1C
containing C-LTCCs. We investigated to which extent these differences are determined by
α1D itself by analyzing the biophysical and pharmacological properties of cloned human
α1D splice variants in tsA-201 cells. Variant α1D 8A, containing exon 8A sequence in repeat
I, yielded α1D protein and L-type currents, whereas no intact protein and currents were …