[HTML][HTML] Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2−/− mouse liver
K Tobe, R Suzuki, M Aoyama, T Yamauchi… - Journal of Biological …, 2001 - ASBMB
Insulin receptor substrate (IRS)-2−/− mice develop diabetes because of insulin resistance in
the liver and failure to undergo β-cell hyperplasia. Here we show by DNA chip microarray
analysis that expression of the sterol regulatory element-binding protein (SREBP)-1 gene, a
downstream target of insulin, was paradoxically increased in 16-week-old IRS-2−/− mouse
liver, where insulin-mediated intracellular signaling events were substantially attenuated.
The expression of SREBP-1 downstream genes, such as the spot 14, ATP citrate-lyase, and …
the liver and failure to undergo β-cell hyperplasia. Here we show by DNA chip microarray
analysis that expression of the sterol regulatory element-binding protein (SREBP)-1 gene, a
downstream target of insulin, was paradoxically increased in 16-week-old IRS-2−/− mouse
liver, where insulin-mediated intracellular signaling events were substantially attenuated.
The expression of SREBP-1 downstream genes, such as the spot 14, ATP citrate-lyase, and …