[HTML][HTML] Angiopoietin-like protein 3 mediates hypertriglyceridemia induced by the liver X receptor
T Inaba, M Matsuda, M Shimamura, N Takei… - Journal of Biological …, 2003 - ASBMB
The KK/San obese and diabetic mouse, a mutant strain from KK obese mice, exhibits
significantly low plasma triglyceride levels. In KK/San mice, genetic analysis identified a
mutation in the gene encoding angiopoietinlike protein 3 (Angptl3), a liver-specific secretory
protein, which had suppressive effect on lipoprotein lipase activity. In the current study, LXR
ligands augmented Angptl3 mRNA expression and protein production in hepatoma cells.
LXR ligands and LXR· retinoid X receptor (RXR) complex increased the promoter activity of …
significantly low plasma triglyceride levels. In KK/San mice, genetic analysis identified a
mutation in the gene encoding angiopoietinlike protein 3 (Angptl3), a liver-specific secretory
protein, which had suppressive effect on lipoprotein lipase activity. In the current study, LXR
ligands augmented Angptl3 mRNA expression and protein production in hepatoma cells.
LXR ligands and LXR· retinoid X receptor (RXR) complex increased the promoter activity of …