[HTML][HTML] Overexpression of human apolipoprotein A-II in mice induces hypertriglyceridemia due to defective very low density lipoprotein hydrolysis
E Boisfer, G Lambert, V Atger, NQ Tran… - Journal of biological …, 1999 - ASBMB
Two lines of transgenic mice, hAIItg-δ and hAIItg-λ, expressing human apolipoprotein (apo)
A-II at 2 and 4 times the normal concentration, respectively, displayed on standard chow
postprandial chylomicronemia, large quantities of very low density lipoprotein (VLDL) and
low density lipoprotein (LDL) but greatly reduced high density lipoprotein (HDL).
Hypertriglyceridemia may result from increased VLDL production, decreased VLDL
catabolism, or both. Post-Triton VLDL production was comparable in transgenic and control …
A-II at 2 and 4 times the normal concentration, respectively, displayed on standard chow
postprandial chylomicronemia, large quantities of very low density lipoprotein (VLDL) and
low density lipoprotein (LDL) but greatly reduced high density lipoprotein (HDL).
Hypertriglyceridemia may result from increased VLDL production, decreased VLDL
catabolism, or both. Post-Triton VLDL production was comparable in transgenic and control …