Transmembrane signaling through CD80 (B7-1) induces growth arrest and cell spreading of human B lymphocytes accompanied by protein tyrosine phosphorylation
M Hirokawa, J Kuroki, A Kitabayashi, AB Miura - Immunology letters, 1996 - Elsevier
We addressed the issue of the role for CD80 (B7-1) expressed on human B cells in
transmembrane signaling. Cross-linking of CD80 on B lymphoma Raji cells induced tyrosine
phosphorylation in 160-, 120-, 55-, 46-and 44-kDa proteins, which was inhibited by
genistein. CD80-mediated signaling resulted in the inhibition of DNA replication of B cells
and induced the changes in morphology like macrophages or fibroblasts. This cell
spreading was inhibited by the pre-treatment of the cells with genistein. These results …
transmembrane signaling. Cross-linking of CD80 on B lymphoma Raji cells induced tyrosine
phosphorylation in 160-, 120-, 55-, 46-and 44-kDa proteins, which was inhibited by
genistein. CD80-mediated signaling resulted in the inhibition of DNA replication of B cells
and induced the changes in morphology like macrophages or fibroblasts. This cell
spreading was inhibited by the pre-treatment of the cells with genistein. These results …