Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care

DC Angus, WT Linde-Zwirble, J Lidicker… - Critical care …, 2001 - journals.lww.com
Measurements and Main Results We linked all 1995 state hospital discharge records (n=
6,621,559) from seven large states with population and hospital data from the US Census,
the Centers for Disease Control, the Health Care Financing Administration, and the
American Hospital Association. We defined severe sepsis as documented infection and
acute organ dysfunction using criteria based on the International Classification of Diseases,
Ninth Revision, Clinical Modification. We validated these criteria against prospective clinical …